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Different studies have reported on antihistamine use in children, with various studies finding evidence that certain antihistamines could be used by children 2 years of age, and other drugs being safer for younger or older children.Please see package insert for additional information and possible updates.Seasonal allergic rhinitis: 60 mg orally twice daily or 180 mg once daily.A dose of 60 mg once daily is recommended as the starting dose in patients with decreased renal function Mechanism of Action Fexofenadine hydrochloride, the major active metabolite of terfenadine, is an antihistamine with selective peripheral H1-receptor antagonist activity.Although typical people use the word “antihistamine” to describe drugs for treating allergies, doctors and scientists use the term to describe a class of drug that opposes the activity of histamine receptors in the body.-receptor are used to treat allergic reactions in the nose (e.g., itching, runny nose, and sneezing) as well as for insomnia.

Itching, sneezing, and inflammatory responses are suppressed by antihistamines that act on H1-receptors.The clinical significance of these findings is unknown.In laboratory animals, no anticholinergic or alpha1-adrenergic blocking effects were observed.Start with lower doses and increase as needed and tolerated. Measure Karbinal ER with an accurate milliliter measuring device.A household teaspoon is not an accurate measuring device and could lead to overdosage.

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